(2R,4S)-2-HydroxyMethyl-4-Boc-aMinopyrrolidine hydrochloride
tert-butyl (3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate
CAS: 1070295-74-7
Molecular Formula: C10H20N2O3
(2R,4S)-2-HydroxyMethyl-4-Boc-aMinopyrrolidine hydrochloride - Names and Identifiers
(2R,4S)-2-HydroxyMethyl-4-Boc-aMinopyrrolidine hydrochloride - Physico-chemical Properties
| Molecular Formula | C10H20N2O3 |
| Molar Mass | 216.28 |
| Density | 1.11 |
| Boling Point | 351.4±35.0 °C(Predicted) |
| pKa | 12.21±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
(2R,4S)-2-HydroxyMethyl-4-Boc-aMinopyrrolidine hydrochloride - Introduction
tert-Butyl N-[(3S,5R)-5-(hydroxymethyl)-3-pyrrolidinyl] carbamate, commonly abbreviated as HBTU, is an organic compound. The following is a description of the nature, use, method and safety information of HBTU:
Nature:
HBTU is a colorless crystalline powder with a chemical formula of C11H16N5O3 and a relative molecular mass of 284.28g/mol. It is stable at room temperature, poorly soluble in water and soluble in organic solvents.
Use:
HBTU is primarily used as an activator in peptide synthesis. It can react with amino acids or peptide segments to facilitate the linkage between amino acids to form longer peptide chains. Therefore, HBTU has important application value in the synthesis of protein or peptide drugs.
Preparation Method:
The synthetic method of HBTU is complicated, involving multiple steps and intermediates. Commonly used preparation methods include the condensation reaction of pyrrolidone with tert-butanol, followed by a substitution reaction with formyl chloride, and then an esterification reaction with carbamic acid. The detailed synthesis process needs to be carried out in a chemical laboratory.
Safety Information:
HBTU is generally safe under normal operating conditions, but laboratory safety procedures must be followed. It may cause irritation to the eyes, skin and respiratory system, so use protective glasses, gloves and a mask. Avoid contact with strong oxidants, and should be sealed when stored, away from fire and heat sources.
It should be noted that since HBTU is a chemical reagent, it should not be used as a drug, but should be operated safely in a laboratory or scientific research environment. During use, correct waste treatment procedures should be followed to avoid pollution to the environment.
Nature:
HBTU is a colorless crystalline powder with a chemical formula of C11H16N5O3 and a relative molecular mass of 284.28g/mol. It is stable at room temperature, poorly soluble in water and soluble in organic solvents.
Use:
HBTU is primarily used as an activator in peptide synthesis. It can react with amino acids or peptide segments to facilitate the linkage between amino acids to form longer peptide chains. Therefore, HBTU has important application value in the synthesis of protein or peptide drugs.
Preparation Method:
The synthetic method of HBTU is complicated, involving multiple steps and intermediates. Commonly used preparation methods include the condensation reaction of pyrrolidone with tert-butanol, followed by a substitution reaction with formyl chloride, and then an esterification reaction with carbamic acid. The detailed synthesis process needs to be carried out in a chemical laboratory.
Safety Information:
HBTU is generally safe under normal operating conditions, but laboratory safety procedures must be followed. It may cause irritation to the eyes, skin and respiratory system, so use protective glasses, gloves and a mask. Avoid contact with strong oxidants, and should be sealed when stored, away from fire and heat sources.
It should be noted that since HBTU is a chemical reagent, it should not be used as a drug, but should be operated safely in a laboratory or scientific research environment. During use, correct waste treatment procedures should be followed to avoid pollution to the environment.
Last Update：2024-04-09 20:49:11
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Product Name: tert-butyl (3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate Visit Supplier Webpage Request for quotation
CAS: 1070295-74-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1070295-74-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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